Childrens Hospital Los Angeles USC Viterbi School of Engineering

GADA Help Manual


    Installation instructions:

    1. Download the GUI from http://biron.usc.edu/~piquereg/GADA and unpack the contents.
    2. Install the Matlab Runtime Component, if not previously installed.

    Contents description:

    • gadagui.exe -- imports an input text file and runs the SBL algorithm.
    • smallexample.txt -- example input text file for gadagui.exe
    • gadareport.exe -- runs the Backward Elimination algorithm and reports CNA
    • smallexample.mat -- example input text file for gadareport.exe

    Usage example:

    1. Prepare <inputfile.txt> with the data with the same format as smallexample.txt; i.e. a tab delimited file with:
      Probeid Sample1 ... SampleN ChrNum Position
    2. Run gadagui.exe which calls the GADA algorithm:
      • Select input file <inputfile.txt>
      • Set output file name <result.mat>
      • Specify algorithm parameters:
          a -- SBL hyperprior parameter
          T -- Minumum T for the Backward Elimination
          M -- Minimum amount of probes in the segments
    3. Run gadareport.exe; i.e. BE adjustment, visualitzation, and CNA report:
      • Select mat file <result.mat>
      • Adjust BE algorithm parameters (parameters cannot be adjusted to a smaller setting than the one that was used in gadagui.exe):
          T -- T for the Backward Elimination
          M -- Minimum amount of probes in the segments
      • CNA visual representation, browsing, report segments